it will no longer be possible to enter and transfer instructions for registration, re-registration and change shareholder data for Medigene AG (ISIN DE000A40ESG2) until further notice.

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1. This Announcement is published by Clearstream Banking AG (CBF), registered office at Mergenthalerallee 61, 65760 Eschborn, Germany, registered with the Commercial Register of the District Court in Frankfurt am Main, Germany, under number HRB 7500.